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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are usually focused on the practical aspects of the research design, like recruitment and consent, adherence, and 프라그마틱 슬롯 추천 the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and participants from different geographical regions. This type of heterogeneity which is vital for pragmatic trials to be reliable and reduce bias in results, is also necessary. However excessive heterogeneity could lead to problems with the design of the trial.

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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They can be used to determine the cause-effect relationship of an intervention and its effects. However, they should not, be used to replace the need for explanation studies.

The pragmatism idea is controversial and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm a physiological or clinical hypothesis and pragmatic trials, which inform the practice and policy decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a practical study that includes recruitment, design, implementation of the intervention, and follow-up.

There is a growing increase in the number pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs) produced 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the subject of pragmatism. It is important to note, however, that the majority of these studies were conducted in primary care settings.